Notes on Genus: Arterivirus

enveloped spheres

Type member: Equine arteritis virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

This is currently the only genus in the family Arteriviridae and is named after the type member, Equine arteritis virus.

Morphology

Virions enveloped and spherical 45-60 nm in diameter, with a core shell of 25-35nm. There are surface patterns but no obvious spikes.

Genome

Monopartite positive sense single-stranded RNA 12-16kb in length and with a 3'-polyA tail.

Genus Genomic Organization

Two large, overlapping ORFs at the 5'-end of the genome encode the major non-structural proteins and are expressed as a fusion protein by ribosomal frameshift. These contain regions with protease, helicase and RNA polymerase motifs. Downstream are up to 9 other genes, most of which encode structural proteins, and these are expressed from a 3'-coterminal nested set of subgenomic RNAs. The major coat protein (N) is at the 3'-end of the genome.

Type Member Genomic Organization

The RNA of 12.7kb is translated into the following products: