Notes on Genus: Avulavirus

enveloped spheres

Type member: Newcastle disease virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Avulavirus is one of nine genera in the family Paramyxoviridae and contains viruses that used to be classified in the genus Rubulavirus, but which infect birds (hence the name avian rubulavirus and translate protein V from an edited RNA transcript. They have a hemagglutinin-neuraminidase attachment protein and do not produce a non-strutural protein C.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 or 7 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N51-53 kDa Coat protein (nucleocapsid)
2P 42-46 kDa Phosphoprotein
3V Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift; not precisely specified in the sequence file headers
4M40 kDa Matrix protein
5F 59-60 kDa Fusion protein: glycosylated envelope protein
6SH 16 kDa Small membrane protein (in some members only)
7H62-68 kDa Hemagglutinin-neuraminidase attachment protein
8L      248-252 kDa Polymerase

Type Member Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N53 kDa Coat protein (nucleocapsid)
2P 42 kDa Phosphoprotein
3V Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift; not precisely specified in the sequence file headers
4M40 kDa Matrix protein
5F 59 kDa Fusion protein: glycosylated envelope protein
6H63 kDa Hemagglutinin-neuraminidase attachment protein
7L      249 kDa Polymerase