Notes on Genus: Bornavirus
Type member: Borna disease virus
The genus Bornavirus
is the only genus in the family Bornaviridae
. It is named from the city of Borna in Germany where the disease caused by the type (and only) member was first identified in horses.
Virions isometric, enveloped, about 90 nm in diameter, with small (7 nm) projections.
Monopartite single-stranded negative sense RNA of about 8.9 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.
Genus Genomic Organization
There are 6 major ORFs with the RNA polymerase at the 5'-end of the genome and the capsid nucleoprotein at the 3'-end.
Type Member Genomic Organization
There are six major ORFs translated from positive sense template RNAs. They are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
|1 ||NP||41 kDa ||Coat protein (nucleocapsid)|
|2||p10 ||9 kDa ||unknown function|
|3||p24||22 kDa ||Phosphoprotein |
|4||M ||16 kDa ||Matrix protein |
|5||G||56 kDa ||Glycoprotein |
|6||L || 180 kDa ||Polymerase |