Notes on Genus: Bornavirus

enveloped spheres

Type member: Borna disease virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Bornavirus is the only genus in the family Bornaviridae. It is named from the city of Borna in Germany where the disease caused by the type (and only) member was first identified in horses.

Morphology

Virions isometric, enveloped, about 90 nm in diameter, with small (7 nm) projections.

Genome

Monopartite single-stranded negative sense RNA of about 8.9 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 major ORFs with the RNA polymerase at the 5'-end of the genome and the capsid nucleoprotein at the 3'-end.

Type Member Genomic Organization

There are six major ORFs translated from positive sense template RNAs. They are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    NP41 kDa Coat protein (nucleocapsid)
2p10 9 kDa unknown function
3p2422 kDa Phosphoprotein
4M 16 kDa Matrix protein
5G56 kDa Glycoprotein
6L 180 kDa Polymerase