Notes on Genus: Ephemerovirus
Type member: Bovine ephemeral fever virus
This is one of the animal virus genera in the family Rhabdoviridae
. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is more than 12kb in size. The name is taken from the type member.
Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.
Monopartite, linear, single-stranded, negative sense RNA, about 15000 nucleotides long.
Genus Genomic Organization
There are the five structural proteins common to all members of the family and several additional genes, encoding a tranmembrane glycoprotein and other proteins of unknown function, between the G and L genes.
Type Member Genomic Organization
The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):
|ORF|| Gene ||Product||Function|
|1 ||N ||49.1 kDa||Coat protein (nucleocapsid) |
|2 ||P||32.2 kDa||Polymerase-associated phosphoprotein |
|3 ||P' ||5.8 kda||P protein overlapping ORF2 |
|4 ||M ||25.5 kda||Matrix protein |
|5 ||G||72.3 kda ||Glycoprotein |
|6 ||GNS||68.8 kDa||Transmembrane glycoprotein |
|7 ||alpha 1||10.7 kDa||unknown function |
|8 ||alpha 2||14.2 kDa||unknown function |
|9 ||alpha 3||5.7 kDa||unknown function |
|10 ||beta||12.3 kDa||unknown function |
|11 ||gamma||13.4 kDa||unknown function |
|12 ||L||249.8 kDa ||Polyprotein with replicase and other functions|