Notes on Genus: Ferlavirus
Type member: Fer-de-Lance paramyxovirus
The genus Ferlavirus
is one of nine genera in the family Paramyxoviridae
and contains contains viruses that infect reptiles. The name is derived from the type species, Fer
Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.
Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.
Genus Genomic Organization
There are 8 transcriptional elements (mRNA species). There is no C protein and the phosphprotein P is produced from an edited transcript.
Type Member Genomic Organization
There are 8 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
|1 ||N||51 kDa || Coat protein (nucleocapsid)|
|2||X ||19 kDa ||Unkown ORF|
|3||P ||47 kDa ||Phosphoprotein produced by RNA editing|
|4||V||25 kDa ||Non-structural protein from same mRNA transcript as P but in a different reading frame |
|5||M||38 kDa ||Matrix protein |
|6||F ||58 kDa ||Fusion protein: glycosylated envelope protein|
|7||HN||62 kDa ||Hemagglutinin-neuraminidase attachment protein|
|8||L ||247 kDa ||Polymerase |