Notes on Genus: Flavivirus

icosahedra

Type member: Yellow fever virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

This is one of the genera in the family Flaviviridae and consists of those viruses with a genome of 10-12kb that encodes three structural proteins (coat protein and two membrane proteins). Members infect both vertebrates and invertebrates and are mostly arthropod-borne. The name is from the Latin flavus = yellow, from the type member, Yellow fever virus.

Morphology

Virions enveloped and spherical about 50 nm in diameter. Mature virions contain two virus-encoded membrane proteins (M and E), while immature virions contain a membrane protein precursor.

Genome

Monopartite positive sense single-stranded RNA about 11kb in length, with a 5'-cap (m-7GpppAmp) and no 3'-polyA tail.

Genus Genomic Organization

There is a single polyprotein of about 380 kDa that is subsequently processed into a number of structural and non-structural proteins:

Type Member Genomic Organization

There is a single polyprotein of about 380 kDa that is subsequently processed into a number of structural and non-structural proteins: