Notes on Genus: Hantavirus
Type member: Hantaan virus
This is one of the four animal virus genera in the family Bunyaviridae
. No non-structural proteins have been identified and the coat protein (N gene) is substantially larger than those of the genera Orthobunyavirus
. The name is derived from the type member, originally isolated from near the Hantaan river, in South Korea.
Virions pleomorphic in shape and size, spheroidal and enveloped, 80-110 nm in diameter. 3 filamentous nucleocapsids per envelope, each 200-3000 nm long (depending on arrangement) and 2-2.5 nm in diameter. Symmetry helical.
Virions composed of 1-2 % nucleic acid, over 50 % protein and 20-30 % lipid.
Linear, tripartite negative sense ssRNA: L (c.
6500 nt), M (c.
3600 nt) and S (1700-2100 nt).
Genus Genomic Organization
Translation of the RNAs produces a polymerase (RNA-L), a protein precursor which is cleaved into two glycoproteins (RNA-M), and the coat protein (RNA-S).
Type Member Genomic Organization
All the RNAs are translated from the complementary strand:
- RNA-L produces a single protein (L) of 246.5 kDa (RNA polymerase)
- RNA-M produces a protein precursor of 126.4 kDa, from which two mature proteins are generated:
- Glycoprotein G1 (63.0 kDa)
- Glycoprotein G2 (52.9 kDa)
- RNA-S produces the N (nucleocapsid, or coat protein) protein of 48.1 kDa