Notes on Genus: Hemivirus
|variable ovoid or spheroid|
Type member: Drosophila melanogaster copia virus
This is one of the genera (distinct phylogenetic lineages) in the retroelement family Pseudoviridae
. DNA synthesis is primed by a half t-RNA molecule, hence the name (from the Greek hemi
Virus-like particles (VLPs) are poorly studied but seem to be non-enveloped, ovoid or spheroid in shape and 60-80 nm in diameter.
The major molecule is a positive sense ssRNA transcript of 4.5-6.5 kb flanked by Long Terminal Repeats (LTRs).
Genus Genomic Organization
The two major genes gag and pol are produced either from a single ORF or from 2 ORFs (either by ribosomal frameshift or via a spliced mRNA). As in other genera of the family, the pol contains protease (PR), integrase (IN) and reverse transcriptase (RT) domains in that order.
Type Member Genomic Organization
There is a single gag-pol ORF of 163 kDa. The gag is translated from a spliced mRNA.