Notes on Genus: Hepacivirus

icosahedra

Type member: Hepatitis C virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

This is one of the genera in the family Flaviviridae and contains viruses with a genome of <10kb that encodes three structural proteins (coat protein and two membrane proteins). The only known natural host is man and they are transmitted through infected blood. The genus is named after the type member, Hepatitis C virus.

Morphology

Virions enveloped and spherical about 50 nm in diameter. Mature virions contain two virus-encoded membrane proteins (E1 and E2) in addition to the coat protein.

Genome

Monopartite positive sense single-stranded RNA about 9.6kb in length, with no 3'-polyA tail.

Genus Genomic Organization

There is a single polyprotein of about 330 kDa that is subsequently processed into a number of structural and non-structural proteins. As in other members of the family, the structural proteins are at the N-terminus of the polyprotein.

Type Member Genomic Organization

There is a single polyprotein of about 330 kDa that is subsequently processed into a number of structural and non-structural proteins: