Notes on Genus: Hepacivirus
Type member: Hepatitis C virus
This is one of the genera in the family Flaviviridae
and contains viruses with a genome of <10kb that encodes three structural proteins (coat protein and two membrane proteins). The only known natural host is man and they are transmitted through infected blood. The genus is named after the type member, Hepa
Virions enveloped and spherical about 50 nm in diameter. Mature virions contain two virus-encoded membrane proteins (E1 and E2) in addition to the coat protein.
Monopartite positive sense single-stranded RNA about 9.6kb in length, with no 3'-polyA tail.
Genus Genomic Organization
There is a single polyprotein of about 330 kDa that is subsequently processed into a number of structural and non-structural proteins. As in other members of the family, the structural proteins are at the N-terminus of the polyprotein.
Type Member Genomic Organization
There is a single polyprotein of about 330 kDa that is subsequently processed into a number of structural and non-structural proteins:
- Coat protein C, 20.7 kDa
- Envelope glycoprotein E1, 20.8 kDa
- Envelope glycoprotein E2, 40.2 kDa
- p7 protein, 6.7 kDa of unknown function incompletely cleaved from an E2-p7 precursor
- Non-structural protein 2, 23.9 kDa
- Non-structural protein 3, 67.2 kDa
- Non-structural protein 4a, 5.8 kDa
- Non-structural protein 4b, 27.3 kDa
- Non-structural protein 5a, 48.7 kDa
- Non-structural protein 5b (polymerase), 65.8 kDa