Notes on Genus: Iflavirus

icosahedra

Type member: Infectious flacherie virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

This genus (the sole member of the family Iflaviridae), contains viruses of invertebrates that belong in the picornavirus "superfamily", and which share a number of features, both of virion structure and genomic organisation, of members of the families Picornaviridae and Dicistroviridae but which form a distinct group in phylogenetic analyses. It is named from the type member, Infectious flacherie virus.

Morphology

Virions isometric (icosahedral), not enveloped 30 nm in diameter.

Genome

Monopartite, linear, positive sense single-stranded RNA of 8.5-10 kb. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a single polyprotein of 330-350 kDa that is subsequently processed into the functional products. The 3 (or sometimes 4) coat proteins are encoded near the N-terminus.

Type Member Genomic Organization

The RNA encodes a single polyprotein of 346 kDa that is subsequently processed into the functional products. The 3 coat proteins are encoded near the N-terminus and the non-structural proteins contain the recognised motifs for the RNA helicase, cysteine protease and the RNA polymerase.