Notes on Genus: Lagovirus

icosahedra

Type member: Rabbit hemorrhagic disease virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Lagovirus (from the Lagomorpha, the mammalian host order of the type member) is one of the genera in the family Caliciviridae. In common with members of the genera Nebovirus and Sapovirus, the coat protein is at the C-terminus of the polyprotein but the genera have different host specificities and are distinct in phylogenetic analyses.

Morphology

Virions isometric (icosahedral), not enveloped, 35-40 nm in diameter, made of 90 dimers of the coat protein. There are 32 cup-shaped depressions at each of the fivefold and threefold axes.

Genome

Monopartite positive sense single-stranded RNA 7.3-7.5 kb in length with a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a polyprotein that has (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains. There is usually an additional small ORF encoding a basic protein that may be a minor structural component of the virion.

Type Member Genomic Organization

The genome of about 7,400 nucleotides is translated into:
  1. Polyprotein of 257.1 kDa with (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains
  2. ORF2 of 12.7 kDa that is probably a minor structural component of the virion