Notes on Genus: Lyssavirus
Type member: Rabies virus
This is one of the animal virus genera in the family Rhabdoviridae
. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is less than 12kb in size and by having members that are not transmitted by arthropod vectors. The name is taken from the greek lyssa
(rage, or fury: the symptoms of infection by the type member).
Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.
Monopartite, linear, single-stranded, negative sense RNA, about 12000 nucleotides long.
Genus Genomic Organization
There are the five structural proteins common to all members of the family.
Type Member Genomic Organization
The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):
| Gene ||Product||Function|
|1||N ||50.6 kDa||Coat protein (nucleocapsid) |
|2||P||33.1 kDa||Polymerase-associated phosphoprotein (NS) |
|3||M ||23.1 kda||Matrix protein |
|4||G||58.5 kda ||Glycoprotein produced from a 57.5 kDa precursor|
|5||L||244.5 kDa ||Polyprotein with replicase and other functions|