Notes on Genus: Metapneumovirus

enveloped spheres

Type member: Avian metapneumovirus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Metapneumovirus is one of nine genera in the family Paramyxoviridae and contains viruses with 8 transcriptional elements. It is named after the Greek meta = after and pneuma = breath.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 13-14 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 8 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N43 kDa Coat protein (nucleocapsid)
2P 32 kDa Phosphoprotein
3M28 kDa Matrix protein
4F 58 kDa Fusion protein: glycosylated envelope protein
5M2   8/21 kDa Transcription processivity factor; two possible ORFs have been identified
6SH19-21 kDa Small hydrophobic membrane protein
7G26-64 kDa Glycoprotein attachment protein
8L 213-231 kDa Polymerase

Type Member Genomic Organization

There are 8 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N43 kDa Coat protein (nucleocapsid)
2P 32 kDa Phosphoprotein
3M28 kDa Matrix protein
4F 58 kDa Fusion protein: glycosylated envelope protein
5M2   8/21 kDa Transcription processivity factor; two possible ORFs have been identified
6SH21 kDa Small hydrophobic membrane protein
7G64 kDa Glycoprotein attachment protein
8L 213 kDa Polymerase