Notes on Genus: Morbillivirus

enveloped spheres

Type member: Measles virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Morbillivirus is one of nine genera in the family Paramyxoviridae and contains contains viruses that produce a non-strutural protein C, a hemagglutinin attachment protein and translate protein V from an edited RNA transcript. It is named from the Latin morbus = disease.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N58 kDa Coat protein (nucleocapsid)
2P 54-55 kDa Phosphoprotein
3C20-21 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame
4V32 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 59-73 kDa Fusion protein: glycosylated envelope protein
7H68-69 kDa Hemagglutinin attachment protein
8L      248 kDa Polymerase

Type Member Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N58 kDa Coat protein (nucleocapsid)
2P 54 kDa Phosphoprotein
3C21 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame
4V32 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 60 kDa Fusion protein: glycosylated envelope protein
7H69 kDa Hemagglutinin attachment protein
8L      248 kDa Polymerase