Notes on Genus: Nebovirus

icosahedra

Type member: Newbury-1 virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Nebovirus (from the names Nebraska and Newbury given to the first isolates of the type member) is one of the genera in the family Caliciviridae. In common with members of the genera Lagovirus and Sapovirus, the coat protein is at the C-terminus of the polyprotein but the genera have different host specificities and are distinct in phylogenetic analyses.

Morphology

Virions isometric (icosahedral), not enveloped, about 37 nm in diameter.

Genome

Monopartite positive sense single-stranded RNA 7.3-7.5 kb in length with a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a polyprotein that has (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains. There is an additional small ORF encoding a basic protein that may be a minor structural component of the virion.

Type Member Genomic Organization

The genome of about 7,450 nucleotides is translated into:
  1. Polyprotein of 239 kDa with (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains
  2. ORF2 of 24 kDa that may be a minor structural component of the virion