Notes on Genus: Nebovirus
Type member: Newbury-1 virus
The genus Nebovirus
(from the names Nebraska and Newbury given to the first isolates of the type member) is one of the genera in the family Caliciviridae
. In common with members of the genera Lagovirus
, the coat protein is at the C-terminus of the polyprotein but the genera have different host specificities and are distinct in phylogenetic analyses.
Virions isometric (icosahedral), not enveloped, about 37 nm in diameter.
Monopartite positive sense single-stranded RNA 7.3-7.5 kb in length with a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.
Genus Genomic Organization
The RNA encodes a polyprotein that has (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains. There is an additional small ORF encoding a basic protein that may be a minor structural component of the virion.
Type Member Genomic Organization
The genome of about 7,450 nucleotides is translated into:
- Polyprotein of 239 kDa with (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains
- ORF2 of 24 kDa that may be a minor structural component of the virion