Notes on Genus: Novirhabdovirus
Type member: Infectious hematopoietic necrosis virus
This is one of the animal virus genera in the family Rhabdoviridae
. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is less than 12kb in size and with a non-viron (NV) protein encoded by a gene situated between the G and L genes. The name reflects the presence of the no
rion protein. The viruses infect fish.
Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.
Monopartite, linear, single-stranded, negative sense RNA, about 11000 nucleotides long.
Genus Genomic Organization
There are the five structural proteins common to all members of the family and an additional gene, encoding a protein that is not incorporated into the virus particle (hence non-virion NV), between the G and L genes.
Type Member Genomic Organization
The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):
|ORF|| Gene ||Product||Function|
|1||N ||42.2 kDa||Coat protein (nucleocapsid) |
|2||P||25.9 kDa||Polymerase-associated phosphoprotein |
|3||M ||21.8 kda||Matrix protein |
|4||G||56.7 kda ||Glycoprotein |
|5||NV||13.2 kDa||Non-virion protein of unknown function|
|6||L||225.2 kDa || Polyprotein with replicase and other functions|