Notes on Genus: Pestivirus
Type member: Bovine viral diarrhea virus 1
This is one of the genera in the family Flaviviridae
and consists of those viruses with a genome of >12kb that encodes four structural proteins (coat protein and three membrane proteins). They also differ from members of other genera in having a leader protease at the N-terminus of the polyprotein, upstream of the coat protein cistron. The name is from the Latin pestis
= plague, from the symptoms caused.
Virions enveloped and spherical about 40-60 nm in diameter. Mature virions contain three virus-encoded membrane proteins (Ems
, E1 and E2) in addition to the coat protein.
Monopartite positive sense single-stranded RNA 12-13kb in length, with no 3'-polyA tail.
Genus Genomic Organization
There is a single polyprotein of 435-450 kDa that is subsequently processed into a number of structural and non-structural proteins.
Type Member Genomic Organization
There is a single polyprotein of about 449.2 kDa that is subsequently processed into a number of structural and non-structural proteins:
- Npro leader protease
- Coat protein C
- Envelope glycoprotein Ems
- Envelope glycoprotein E1
- Envelope glycoprotein E2
- p7 protein of unknown function
- Non-structural protein 2
- Non-structural protein 3 (protease and helicase activity)
- Non-structural protein 4a
- Non-structural protein 4b
- Non-structural protein 5a
- Non-structural protein 5b (polymerase)