Notes on Genus: Pestivirus

icosahedra

Type member: Bovine viral diarrhea virus 1

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

This is one of the genera in the family Flaviviridae and consists of those viruses with a genome of >12kb that encodes four structural proteins (coat protein and three membrane proteins). They also differ from members of other genera in having a leader protease at the N-terminus of the polyprotein, upstream of the coat protein cistron. The name is from the Latin pestis = plague, from the symptoms caused.

Morphology

Virions enveloped and spherical about 40-60 nm in diameter. Mature virions contain three virus-encoded membrane proteins (Ems, E1 and E2) in addition to the coat protein.

Genome

Monopartite positive sense single-stranded RNA 12-13kb in length, with no 3'-polyA tail.

Genus Genomic Organization

There is a single polyprotein of 435-450 kDa that is subsequently processed into a number of structural and non-structural proteins.

Type Member Genomic Organization

There is a single polyprotein of about 449.2 kDa that is subsequently processed into a number of structural and non-structural proteins: