Notes on Genus: Pneumovirus

enveloped spheres

Type member: Human respiratory syncytial virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Pneumovirus is one of nine genera in the family Paramyxoviridae and contains viruses with 10 transcriptional elements. It is named after the Greek pneuma = breath.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 10 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    NS115-16 kDa Non-structural protein 1
2NS215 kDa Non-structural protein 2
3    N43-44 kDa Coat protein (nucleocapsid)
4P 27 kDa Phosphoprotein
5M29 kDa Matrix protein
6SH7-9 kDa Small hydrophobic membrane protein
7G28-33 kDa Glycoprotein attachment protein
8F 64 kDa Fusion protein: glycosylated envelope protein
9M2 11/21-22 kDa Transcription processivity factor; two possible ORFs have been identified
10L 250 kDa Polymerase

Type Member Genomic Organization

There are 10 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    NS116 kDa Non-structural protein 1
2NS215 kDa Non-structural protein 2
3    N43 kDa Coat protein (nucleocapsid)
4P 27 kDa Phosphoprotein
5M29 kDa Matrix protein
6SH7 kDa Small hydrophobic membrane protein
7G33 kDa Glycoprotein attachment protein
8F 64 kDa Fusion protein: glycosylated envelope protein
9M2 11/22 kDa Transcription processivity factor; two possible ORFs have been identified
10L 250 kDa Polymerase