Notes on Genus: Pseudovirus
|variable ovoid or spheroid|
Type member: Saccharomyces cerevisiae Ty1 virus
This is one of the genera (distinct phylogenetic lineages) in the retroelement family Pseudoviridae
. DNA synthesis is primed by a complete t-RNA molecule. The name reflects uncertainty as to whether to regard these elements as viruses.
Virus-like particles (VLPs) are poorly studied but seem to be non-enveloped, ovoid or spheroid in shape and 60-80 nm in diameter.
The major molecule is a positive sense ssRNA transcript of 4.5-12 kb flanked by Long Terminal Repeats (LTRs).
Genus Genomic Organization
The two major genes gag and pol are produced from 2 ORFs by ribosomal frameshift. As in other genera of the family, the pol contains protease (PR), integrase (IN) and reverse transcriptase (RT) domains in that order.
Type Member Genomic Organization
The two major genes are
- gag: structural polyprotein of 49 kDa
- pol: polymerase of c. 150 kDa consisting of the protease (PR), integrase (IN) and reverse transcriptase (RT)