Notes on Genus: Respirovirus

enveloped spheres

Type member: Sendai virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Respirovirus is one of nine genera in the family Paramyxoviridae and contains viruses that produce a non-strutural protein C, a hemagglutinin-neuraminidase attachment protein and translate protein V from an edited RNA transcript. It is named after the Latin respirare = to breathe.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N57-58 kDa Coat protein (nucleocapsid)
2P 63-67 kDa Phosphoprotein
3C24-26 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame; some isolates may also produce a shorter Y1 (21 kDa) protein
4V24 kDa Produced from the P transcript by RNA editing in some viruses: shares the N-terminus of P but then has a frame shift
5M38-40 kDa Matrix protein
6F 60-61 kDa Fusion protein: glycosylated envelope protein
7HN63-65 kDa Hemagglutinin-neuraminidase attachment protein
8L 253-259 kDa Polymerase

Type Member Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N57 kDa Coat protein (nucleocapsid)
2P 63 kDa Phosphoprotein
3C24 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame; some isolates may also produce a shorter Y1 (21.3 kDa) protein
4V40 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 61 kDa Fusion protein: glycosylated envelope protein
7HN63 kDa Hemagglutinin-neuraminidase attachment protein
8L      253 kDa Polymerase