Notes on Genus: Senecavirus

icosahedra

Type member: Seneca valley virus

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
Curated Sequences

General Description

The genus Senecavirus (from the type member Seneca valley virus) is one of the genera in the family Picornaviridae. Genome organisation is fairly conserved within the family but members of this genus have a 5'-UTR which has no polyC tract, there is a leader protein which is not a protease and the 2A protein is extremely small.

Morphology

Virions isometric (icosahedral), not enveloped 30 nm in diameter, made of 60 units (protomers) each consisting of one molecule of each of three surface coat proteins.

Genome

Monopartite positive sense single-stranded RNA 7.3 kb in length. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a single polyprotein that is subsequently processed into the functional products. The major structural proteins are encoded near the N-terminus.

Type Member Genomic Organization

The genome of about 7,300 nucleotides is translated into a single polyprotein, which is subsequently processed into the mature protein products.