Notes on Family: Parvoviridae
- Members of this Family
- General Description
- Genera in the Family
- All Known Sequences
- Curated Sequences
General DescriptionThis family consists of viruses that infect vertebrates or invertebrates and which have linear single-stranded monopartite DNA genomes. The virions and the genomes are small, hence the name (from the latin parvus="small".
MorphologyVirions isometric (icosahedral), not enveloped, 18-26 nm in diameter, made of 60 units of the capsid protein.
GenomenLinear, single-stranded monopartite DNA, 4-6 kb long.
Genera in the FamilyThere are two subfamilies and several genera within each, based on genome organisation and phylogenetic analysis:
Subfamily Parvovirinae: infect vertebrates
- Amdovirus: Organised like Parvovirus but phylogenetically distinct and without PLA2 enzymatic core in the VP1-specific region
- Bocavirus: Organised like Parvovirus but phylogenetically distinct and with genome about 5.5 kb
- Dependovirus: DNA molecules have inverted terminal repeats and 3 mRNA promoters; efficient replication usually depends upon helper adeno- or herpes- viruses
- Erythrovirus: DNA molecules have inverted terminal repeats and 1 mRNA promoter
- Parvovirus: DNA molecules have terminal hairpins and 2 mRNA promoters; genome about 5.1 kb
- Brevidensovirus: DNA 4 kb; virions contain mainly negative sense DNA
- Densovirus: DNA 6 kb; ambisense coding strategy with structural and non-structural proteins on different strands
- Iteravirus: DNA 5 kb; virions with similar amounts of each polarity DNA
- Pefudensovirus: DNA 5.5 kb, organised like Densovirus but phylogenetically distinct and with PLA2 motif located in the C-terminal of the small ORF rather than in VP1