Notes on Genus: Amdovirus
Type member: Aleutian mink disease virus
This is one of the genera in the subfamily Parvovirinae
, the vertebrate pathogens in the family Parvoviridae
. As in the genus Parvovirus
, there are hairpin structures at both ends of the genome but the two genera are phylogenetically distinct and the usual PLA2 enzymatic core is not present in the VP1-specific region. It is likely that the pattern of protein expression is also more complex. The name is derived from the type member, Aleutian mink disease virus
Virions isometric (icosahedral), not enveloped, 18-26 nm in diameter, made of 60 units of the capsid protein.
Linear, single-stranded monopartite DNA, about 4.8 kb long with hairpin loops at both ends of the genome.
Genus Genomic Organization
As in other members of the subfamily, there are two major ORFs on the same strand. These encode the non-structural (replication) protein and the capsid protein. mRNA splicing may result in products that differ from those of simple computer predictions but which have not always been experimentally determined. The capsid protein may also undergo proteolytic cleavage.
Type Member Genomic Organization
There are 2 major ORFs in the same orientation:
- Non-structural protein NS1, 67.3 kDa
- Capsid protein VP1, 73.5 kDa