Notes on Genus: Aquamavirus
Type member: Aquamavirus A
The genus Aquamavirus
mmal virus) is one of the genera in the family Picornaviridae
. Genome organisation is fairly conserved within the family but members of this genus have small (<7 kb) genomes, no leader protease and two VPg proteins.
Virions isometric (icosahedral), not enveloped 30 nm in diameter, made of 60 units (protomers) each consisting of one molecule of each of three surface coat proteins and with a fourth internal capsid protein.
Monopartite positive sense single-stranded RNA 6.7 kb in length. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.
Genus Genomic Organization
The RNA encodes a single polyprotein that is subsequently processed into the functional products. The major structural proteins are encoded at the N-terminus.
Type Member Genomic Organization
The genome of about 6,700 nucleotides is translated into a single polyprotein, which is subsequently processed into thirteen products:
||Coat protein VP4 and VP2 precursor|
||25.6 kDa||Coat protein VP3 (surface capsid protein)|
||20.4 kDa||Coat protein VP1 (surface capsid protein)|
||3.0 kDa||non-structural protein|
||12.4 kDa||non-structural protein|
||33.2 kDa||non-structural protein|
||12.2 kDa||non-structural protein|
||2.5 kDa||Genome-linked protein (VPg1)|
||2.5 kDa||Genome-linked protein (VPg2)|