Notes on Genus: Aquamavirus


Type member: Aquamavirus A


General Description

The genus Aquamavirus (aquatic mammal virus) is one of the genera in the family Picornaviridae. Genome organisation is fairly conserved within the family but members of this genus have small (<7 kb) genomes, no leader protease and two VPg proteins.


Virions isometric (icosahedral), not enveloped 30 nm in diameter, made of 60 units (protomers) each consisting of one molecule of each of three surface coat proteins and with a fourth internal capsid protein.


Monopartite positive sense single-stranded RNA 6.7 kb in length. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a single polyprotein that is subsequently processed into the functional products. The major structural proteins are encoded at the N-terminus.

Type Member Genomic Organization

The genome of about 6,700 nucleotides is translated into a single polyprotein, which is subsequently processed into thirteen products:
1A+1B   28.6 kDa Coat protein VP4 and VP2 precursor
1C 25.6 kDaCoat protein VP3 (surface capsid protein)
1D 20.4 kDaCoat protein VP1 (surface capsid protein)
2A1 3.0 kDanon-structural protein
2A2 11.6 kDa non-structural protein
2B 12.4 kDanon-structural protein
2C 33.2 kDanon-structural protein
3A 12.2 kDanon-structural protein
3B1 2.5 kDaGenome-linked protein (VPg1)
3B2 2.5 kDaGenome-linked protein (VPg2)
3C 21.9 kDaprotease
3D 53.9 kDapolymerase