Notes on Genus: Bocavirus


Type member: Bovine parvovirus


General Description

This is one of the genera in the subfamily Parvovirinae, the vertebrate pathogens in the family Parvoviridae. As in the genus Parvovirus, there are hairpin structures at both ends of the genome but the two genera are phylogenetically distinct and the genome is larger.


Virions isometric (icosahedral), not enveloped, 18-26 nm in diameter, made of 60 units of the capsid protein.


Linear, single-stranded monopartite DNA, about 5.5 kb long with hairpin loops at both ends of the genome.

Genus Genomic Organization

As in other members of the subfamily, there are two major ORFs on the same strand. These encode the non-structural (replication) protein and the capsid protein. mRNA splicing may result in products that differ from those of simple computer predictions but which have not always been experimentally determined. The capsid protein may also undergo proteolytic cleavage. An additional putative "middle ORF" has been identified.

Type Member Genomic Organization

There are 3 major ORFs in the same orientation and four possible major protein products:
  1. Non-structural protein NS1, 81.1 kDa
  2. Capsid protein VP2 Putative "middle ORF", 24.8 kDa
  3. Capsid protein VP2, 75.1 kDa
  4. Capsid protein VP3 (60.2 kDa) with the same C-terminus as VP2