Notes on Genus: Bornavirus

enveloped spheres

Type member: Borna disease virus

Contents

• Members of this Genus
• General Description
• Morphology
• Electron Micrograph
• Genome
• Genus Genomic Organization
• Genome Map
• Type Member Genomic Organization
• All Known Sequences
• Curated Sequences

General Description

The genus Bornavirus is the only genus in the family Bornaviridae. It is named from the city of Borna in Germany where the disease caused by the type (and only) member was first identified in horses.

Morphology

Virions isometric, enveloped, about 90 nm in diameter, with small (7 nm) projections.

Genome

Monopartite single-stranded negative sense RNA of about 8.9 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 major ORFs with the RNA polymerase at the 5'-end of the genome and the capsid nucleoprotein at the 3'-end.

Type Member Genomic Organization

There are six major ORFs translated from positive sense template RNAs. They are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:

1    	NP	41 kDa	Coat protein (nucleocapsid)
2	p10	9 kDa	unknown function
3	p24	22 kDa	Phosphoprotein
4	M	16 kDa	Matrix protein
5	G	56 kDa	Glycoprotein
6	L	180 kDa	Polymerase