Notes on Genus: Lagovirus
Type member: Rabbit hemorrhagic disease virus
The genus Lagovirus
(from the Lago
morpha, the mammalian host order of the type member) is one of the genera in the family Caliciviridae
. In common with members of the genera Nebovirus
, the coat protein is at the C-terminus of the polyprotein but the genera have different host specificities and are distinct in phylogenetic analyses.
Virions isometric (icosahedral), not enveloped, 35-40 nm in diameter, made of 90 dimers of the coat protein. There are 32 cup-shaped depressions at each of the fivefold and threefold axes.
Monopartite positive sense single-stranded RNA 7.3-7.5 kb in length with a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.
Genus Genomic Organization
The RNA encodes a polyprotein that has (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains. There is usually an additional small ORF encoding a basic protein that may be a minor structural component of the virion.
Type Member Genomic Organization
The genome of about 7,400 nucleotides is translated into:
- Polyprotein of 257.1 kDa with (from N- to C- termini) helicase, VPg, protease, polymerase and coat protein domains
- ORF2 of 12.7 kDa that is probably a minor structural component of the virion