Notes on Genus: Novirhabdovirus

enveloped bacilliform

Type member: Infectious hematopoietic necrosis virus

General Description

This is one of the animal virus genera in the family Rhabdoviridae. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is less than 12kb in size and with a non-viron (NV) protein encoded by a gene situated between the G and L genes. The name reflects the presence of the non-virion protein. The viruses infect fish.

Morphology

Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.

Genome

Monopartite, linear, single-stranded, negative sense RNA, about 11000 nucleotides long.

Genus Genomic Organization

There are the five structural proteins common to all members of the family and an additional gene, encoding a protein that is not incorporated into the virus particle (hence non-virion NV), between the G and L genes.

Type Member Genomic Organization

The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):

ORF	Gene	Product	Function
1	N	42.2 kDa	Coat protein (nucleocapsid)
2	P	25.9 kDa	Polymerase-associated phosphoprotein
3	M	21.8 kda	Matrix protein
4	G	56.7 kda	Glycoprotein
5	NV	13.2 kDa	Non-virion protein of unknown function
6	L	225.2 kDa	Polyprotein with replicase and other functions