Notes on Genus: Pegivirus
Type member: Pegivirus A
This is one of the genera in the family Flaviviridae
and consists of those viruses with a genome of <10kb that appears not to encode a core protein. All members of the genus described to date share an ability to persist in their natural hosts and lack any identified pathogenicity.The name is from â€œPeâ€ for persistent and â€œgâ€ for â€œGâ€ virus, referring to the historical names of the constituent viruses, GB virus and hepatitis G virus.
Virions enveloped and spherical about 40-60 nm in diameter. Mature virions contain two virus-encoded membrane proteins ( E1 and E2).
Monopartite positive sense single-stranded RNA 9.0-9.5 kb in length, with no 3'-polyA tail.
Genus Genomic Organization
There is a single polyprotein of 310-340 kDa that is subsequently processed into a number of structural and non-structural proteins.
Type Member Genomic Organization
In Pegivirus B, the single polyprotein of about 336 kDa is subsequently processed into a number of structural and non-structural proteins:
- Envelope glycoprotein E1, 26 kDa
- Envelope glycoprotein E2, 38 kDa
- 26 kDa protein of unknown function
- Non-structural protein 2, 28 kDa
- Non-structural protein 3 (protease and helicase activity), 67 kDa
- Non-structural protein 4a, 8 kDa
- Non-structural protein 4b, 30 kDa
- Non-structural protein 5a, 50 kDa
- Non-structural protein 5b (polymerase), 64 kDa