Notes on Genus: Pegivirus

icosahedra
icosahedra

Type member: Pegivirus A

Contents

General Description

This is one of the genera in the family Flaviviridae and consists of those viruses with a genome of <10kb that appears not to encode a core protein. All members of the genus described to date share an ability to persist in their natural hosts and lack any identified pathogenicity.The name is from “Pe” for persistent and “g” for “G” virus, referring to the historical names of the constituent viruses, GB virus and hepatitis G virus.

Morphology

Virions enveloped and spherical about 40-60 nm in diameter. Mature virions contain two virus-encoded membrane proteins ( E1 and E2).

Genome

Monopartite positive sense single-stranded RNA 9.0-9.5 kb in length, with no 3'-polyA tail.

Genus Genomic Organization

There is a single polyprotein of 310-340 kDa that is subsequently processed into a number of structural and non-structural proteins.

Type Member Genomic Organization

In Pegivirus B, the single polyprotein of about 336 kDa is subsequently processed into a number of structural and non-structural proteins:
  • Envelope glycoprotein E1, 26 kDa
  • Envelope glycoprotein E2, 38 kDa
  • 26 kDa protein of unknown function
  • Non-structural protein 2, 28 kDa
  • Non-structural protein 3 (protease and helicase activity), 67 kDa
  • Non-structural protein 4a, 8 kDa
  • Non-structural protein 4b, 30 kDa
  • Non-structural protein 5a, 50 kDa
  • Non-structural protein 5b (polymerase), 64 kDa