Notes on Genus: Salivirus


Type member: Salivirus A


General Description

The genus Salivirus (Stool Aichi-like virus) is one of the genera in the family Picornaviridae. Genome organisation is fairly conserved within the family but members of this genus have a leader protease and a distinctive 2A protein which is a putative trypsin-like protease.


Virions isometric (icosahedral), not enveloped 30 nm in diameter, made of 60 units (protomers) each consisting of one molecule of each of three surface coat proteins and with a fourth internal capsid protein.


Monopartite positive sense single-stranded RNA about 8 kb in length. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a single polyprotein that is subsequently processed into the functional products. The major structural proteins are encoded at the N-terminus.

Type Member Genomic Organization

The genome of about 8,000 nucleotides is translated into a single polyprotein, which is subsequently processed into twelve products:
L   12.8 kDa Leader protease
1A+1B   37.6 kDa Coat protein VP4+VP2 precursor
1C 24.4 kDa Coat protein VP3 (surface capsid protein)
1D 29.6 kDa Coat protein VP1 (surface capsid protein)
2A 12.6 kDa non-structural protein (protease)
2B 15.7 kDa non-structural protein
2C 37.8 kDa non-structural protein
3A 8.2 kDa non-structural protein
3B 3.2 kDa Genome-linked protein (VPg)
3C 20.9 kDa protease
3D 52.9 kDa polymerase