Notes on Genus: Senecavirus


Type member: Seneca valley virus


General Description

The genus Senecavirus (from the type member Seneca valley virus) is one of the genera in the family Picornaviridae. Genome organisation is fairly conserved within the family but members of this genus have a 5'-UTR which has no polyC tract, there is a leader protein which is not a protease and the 2A protein is extremely small.


Virions isometric (icosahedral), not enveloped 30 nm in diameter, made of 60 units (protomers) each consisting of one molecule of each of three surface coat proteins.


Monopartite positive sense single-stranded RNA 7.3 kb in length. There is a genome-linked protein (VPg) at the 5'-terminus and a 3'-polyA tail.

Genus Genomic Organization

The RNA encodes a single polyprotein that is subsequently processed into the functional products. The major structural proteins are encoded near the N-terminus.

Type Member Genomic Organization

The genome of about 7,300 nucleotides is translated into a single polyprotein, which is subsequently processed into the mature protein products.