Notes on Genus: Thogotovirus
enveloped spheres or pleomorphic
Type member: Thogoto virus
The genus Thogotovirus
is one of the genera in the family Orthomyxoviridae
. It is named from the type member. The viruses differ from those in most other genera of the family in having insect (tick) vectors and 6 or 7 apparently monocistronic genome segments. Distantly related tick-borne viruses are classifed in the genus Quaranjavirus
Virions spherical or pleomorphic, enveloped, 80-120 nm in diameter, with projections 4-6 nm in diameter and 10-14 nm long.
Single-stranded negative sense RNA in 6 or 7 segments totalling about 10.5 kb. The segments do not have a genome-linked protein (VPg) at their 5'-terminus nor a 3'-polyA tail.
Genus Genomic Organization
There are 6 or 7 RNA segments, most of which encode a single protein.
Type Member Genomic Organization
There are 6 RNA segments:
- RNA1 (2368 nts) encodes a basic polymerase (PB2) of 88.0 kDa
- RNA2 (2396 nts) encodes a basic polymerase (PB1) of 81.3 kDa
- RNA3 (2308 nts) encodes an acid polymerase (PA) of 71.4 kDa
- RNA4 (1882 nts) encodes a glycoprotein (G) of 57.5 kDa
- RNA5 (1841 nts) encodes the coat protein (Nucleoprotein, NP) of 51.8 kDa
- RNA6 (955 nts) encodes a matrix protein (M) of 29.8 kDa and an interferon antagonist (ML) of 34.4 kDa