Sequence of DPV Vesicular stomatitis Indiana virus

Vesicular stomatitis Indiana virus, complete genome.

ACC No: J02428

Dated: 2001-01-24 | Length: 11161 | CRC: -623547128

                !!NA_SEQUENCE 1.0
ID   RHPSLIN    standard; RNA; VRL; 11161 BP.
XX
AC   J02428; J02430; J02431; J02432; J02434; J02435; J02436; J02437; J02438;
AC   K00519; K00520; K00625; K01068; K01069; K01070; K01638; K01639;
XX
SV   J02428.1
XX
DT   13-JUN-1985 (Rel. 06, Created)
DT   24-JAN-2001 (Rel. 66, Last updated, Version 7)
XX
DE   Vesicular stomatitis virus (Indiana serotype) complete genome.
XX
KW   complete genome; G protein; glycoprotein; leader RNA; NS protein;
KW   nucleocapsid protein; polymerase; protein L; protein M; protein N.
XX
OS   Vesicular stomatitis virus
OC   Viruses; ssRNA negative-strand viruses; Mononegavirales; Rhabdoviridae;
OC   Vesiculovirus.
XX
RN   [1]
RP   1-47
RX   MEDLINE; 79023075.
RA   Colonno R.J., Banerjee A.K.;
RT   "Complete nucleotide sequence of the leader RNA synthesized in vitro by
RT   vesicular stomatitis virus";
RL   Cell 15:93-101(1978).
XX
RN   [2]
RP   1172-1379
RX   MEDLINE; 79074267.
RA   McGeoch D.J., Turnbull N.T.;
RT   "Analysis of the 3'-terminal nucleotide sequence of vesicular stomatitis
RT   virus N protein mRNA";
RL   Nucleic Acids Res. 5:4007-4024(1978).
XX
RN   [3]
RP   1285-1434
RX   MEDLINE; 80001959.
RA   Mcgeoch D.J.;
RT   "Structure of the gene N: gene NS intercistronic junction in the genome of
RT   vesicular stomatitis virus";
RL   Cell 17:673-681(1979).
XX
RN   [4]
RP   1287-1376, 2110-2199
RX   MEDLINE; 80052083.
RA   Rose J.K., Iverson L.;
RT   "Nucleotide sequences from the 3'-ends of vesicular stomatitis virus mRNA's
RT   as determined from cloned DNA";
RL   J. Virol. 32:404-411(1979).
XX
RN   [5]
RP   1-201
RX   MEDLINE; 80012831.
RA   McGeoch D.J., Dolan A.;
RT   "Sequence of 200 nucleotides at the 3'-terminus of the genome RNA of
RT   vesicular stomatitis virus";
RL   Nucleic Acids Res. 6:3199-3211(1979).
XX
RN   [6]
RP   1-114
RX   MEDLINE; 80056579.
RA   Rowlands D.J.;
RT   "Sequences of vesicular stomatitis virus RNA in the region coding for
RT   leader RNA, N protein mRNA, and their junction";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:4793-4797(1979).
XX
RN   [7]
RP   51-219, 1337-1434, 2160-2378, 2940-3099, 4614-4767, 11056-11112
RX   MEDLINE; 80132490.
RA   Rose J.K.;
RT   "Complete intergenic and flanking sequences from the genome of vesicular
RT   stomatitis virus";
RL   Cell 19:415-421(1980).
XX
RN   [8]
RP   1-104
RX   MEDLINE; 80199915.
RA   Rowlands D.J., Grabau E., Spindler K., Jones C., Semler B.L., Holland J.;
RT   "Virus proteins changes and RNA termini alterations evolving during
RT   persistent infection";
RL   Cell 19:871-880(1980).
XX
RN   [9]
RP   1-81
RX   MEDLINE; 81009726.
RA   Keene J.D., Schubert M., Lazzarini R.A.;
RT   "Intervening sequence between the eader region and the nucleocapsid gene of
RT   vesicular stomatitis virus RNA";
RL   J. Virol. 33:789-794(1980).
XX
RN   [10]
RP   11032-11122
RX   MEDLINE; 80185165.
RA   Schubert M., Keene J.D., Herman R.C., Lazzarini R.A.;
RT   "Site on the vesicular stomatitis virus genome specifying polyadenylation
RT   and the end of the L gene mRNA";
RL   J. Virol. 34:550-559(1980).
XX
RN   [11]
RP   3049-3236, 4244-4713
RX   MEDLINE; 81054676.
RA   Rose J.K., Welch W.J., Sefton B.M., Esch F.S., Ling N.C.;
RT   "Vesicular stomatitis virus glycoprotein is anchored in the viral membrane
RT   by a hydrophobic domain near the COOH terminus";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:3884-3888(1980).
XX
RN   [12]
RP   11072-11161
RX   MEDLINE; 81218418.
RA   Schubert M., Lazzarini R.A.;
RT   "In vivo transcription of the 5'-terminal extracistronic region of
RT   vesicular stomatitis virus RNA";
RL   J. Virol. 38:256-262(1981).
XX
RN   [13]
RP   2209-3039, 3049-4713
RX   MEDLINE; 82010868.
RA   Rose J.K., Gallione C.J.;
RT   "Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus
RT   G and M proteins determined from cDNA clones containing the complete coding
RT   regions";
RL   J. Virol. 39:519-528(1981).
XX
RN   [14]
RP   51-1376, 1386-2199, 1386-2199, 1386-2199
RX   MEDLINE; 82010869.
RA   Gallione C.J., Greene J.R., Iverson L.E., Rose J.K.;
RT   "Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus
RT   N and NS proteins";
RL   J. Virol. 39:529-535(1981).
XX
RN   [15]
RP   1-76
RX   MEDLINE; 82269135.
RA   Isaac C.L., Keene J.D.;
RT   "RNA polymerase-associated interactions near template promoter sequences of
RT   defective interfering particles of vesicular stomatitis virus";
RL   J. Virol. 43:241-249(1982).
XX
RN   [16]
RP   4723-5028
RX   MEDLINE; 83090449.
RA   De B.K., Perrault J.;
RT   "Sequence signal involved in the generation of an internally deleted
RT   defective interfering RNA from vesicular stomatitis virus";
RL   Nucleic Acids Res. 10:6919-6930(1982).
XX
RN   [17]
RP   4637-4996, 10796-11161
RX   MEDLINE; 83164321.
RA   Yang F., Lazzarini R.A.;
RT   "Analysis of the recombination event generating a vesticular stomatitis
RT   virus deletion defective interfering particle";
RL   J. Virol. 45:766-772(1983).
XX
RN   [18]
RP   1-100, 1386-1435
RX   MEDLINE; 83147876.
RA   Piwnica-Worms H., Keene J.D.;
RT   "Sequential synthesis of small capped RNA transcripts in vitro by vesicular
RT   stomatitis virus";
RL   Virology 125:206-218(1983).
XX
RN   [19]
RP   4723-11102
RX   MEDLINE; 84268017.
RA   Schubert M., Harmison G.G., Meier E.;
RT   "Primary structure of the vesicular stomatitis virus polymerase (L) gene:
RT   evidence for a high frequency of mutations";
RL   J. Virol. 51:505-514(1984).
XX
RN   [20]
RP   1723-1726, 1959-1961
RA   Rose J.K.;
RT   ;
RL   Unpublished.
XX
RN   [21]
RP   1-66
RX   MEDLINE; 85116972.
RA   Wilusz J., Youngner J.S., Keene J.D.;
RT   "Base mutations in the terminal noncoding regions of the genome of
RT   vesicular stomatitis virus isolated from persistent infections of L cells";
RL   Virology 140:249-256(1985).
XX
DR   SPTREMBL; Q86125; Q86125.
DR   SWISS-PROT; P03519; VMAT_VSVSJ.
DR   SWISS-PROT; P03520; RRPP_VSVSJ.
DR   SWISS-PROT; P03521; NCAP_VSVSJ.
DR   SWISS-PROT; P03522; VGLG_VSVSJ.
XX
CC   [20]  revises [14].
CC   Vesicular stomatitis virus consists of a single-sranded RNA genome
CC   in the antimessage (-) sense.  The sequence reported here is the
CC   complementary (+) strand.
CC   In the sequence below, positions 1-201 are from [5]; positions
CC   202-1376 are from [14]; positions 1377-1385 are from [3]; positions
CC   1386-2199 are from [14]; positions 2200-2208 are from [7];
CC   positions 2209-3039 are from [13]; positions 3040-3048 are from
CC   [7]; positions 3049-4713 are from [13]; positions 4714-4722 are
CC   from [7]; positions 4723-10795 are from [19]; and positions
CC   10796-11161 are from [17].
CC   [19] found several variations among the clones sequenced (see table
CC   4 in [19]).  These could be reverse transcriptase errors or actual
CC   variations among VSV genomes.
CC   [20] is a revision of [14] reported in (Gill et al.; J. Virol. 55,
CC   60-66 (1985)).
CC   Complete source information:
CC   VSV (Indiana serotype): Colorado strain [2],[3],[5]; Mudd Summers
CC   strain [6],[9],[10],[12],[19]; San Juan strain [4],[7],[11],[13],
CC   [14]; tsG31 [8], heat-resistant [9],[16],[17]; wild type [21];
CC   unreported strain [1],[15],[18]; viral RNA, cDNA to viral RNA,
CC   mRNA, and cDNA to mRNA.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1. .11161
FT                   /db_xref="taxon:11276"
FT                   /note="tsG31, heat-resistant; wild type"
FT                   /organism="Vesicular stomatitis virus"
FT                   /serotype="Indiana"
FT   variation       4. .6
FT                   /note="aag in wild type; gac in PI-A [21]"
FT   variation       21
FT                   /note="a in wild type; c in PI-A; t in PI-B [21]"
FT   variation       37
FT                   /note="t in tsG31; a in CAR4 [8]"
FT   variation       44
FT                   /note="a in wild type; g in PI-A [21]"
FT   unsure          44. .46
FT                   /note="aaa or aaaa in [1]"
FT   variation       48
FT                   /note="t in tsG31; g in CAR4 [8]"
FT   mRNA            51. .1376
FT                   /product="N mRNA"
FT   variation       61
FT                   /note="a in wild type; g in PI-A [21]"
FT   CDS             64. .1332
FT                   /codon_start=1
FT                   /db_xref="SWISS-PROT:P03521"
FT                   /note="nucleocapsid (N) protein"
FT                   /protein_id="AAA48367.1"
FT                   /translation="MSVTVKRIIDNTVIVPKLPANEDPVEYPADYFRKSKEIPLYINTT
FT                   KSLSDLRGYVYQGLKSGNVSIIHVNSYLYGALKDIRGKLDKDWSSFGINIGKAGDTIGI
FT                   FDLVSLKALDGVLPDGVSDASRTSADDKWLPLYLLGLYRVGRTQMPEYRKKLMDGLTNQ
FT                   CKMINEQFEPLVPEGRDIFDVWGNDSNYTKIVAAVDMFFHMFKKHECASFRYGTIVSRF
FT                   KDCAALATFGHLCKITGMSTEDVTTWILNREVADEMVQMMLPGQEIDKADSYMPYLIDF
FT                   GLSSKSPYSSVKNPAFHFWGQLTALLLRSTRARNARQPDDIEYTSLTTAGLLYAYAVGS
FT                   SADLAQQFCVGDNKYTPDDSTGGLTTNAPPQGRDVVEWLGWFEDQNRKPTPDMMQYAKR
FT                   AVMSLQGLREKTIGKYAKSEFDK"
FT   mRNA            1386. .2199
FT                   /product="NS mRNA"
FT   CDS             1396. .2193
FT                   /codon_start=1
FT                   /db_xref="SWISS-PROT:P03520"
FT                   /note="NS protein"
FT                   /protein_id="AAA48368.1"
FT                   /translation="MDNLTKVREYLKSYSRLDQAVGEIDEIEAQRAEKSNYELFQEDGV
FT                   EEHTKPSYFQAADDSDTESEPEIEDNQGLYAQDPEAEQVEGFIQGPLDDYADEEVDVVF
FT                   TSDWKPPELESDEHGKTLRLTSPEGLSGEQKSQWLSTIKAVVQSAKYWNLAECTFEASG
FT                   EGVIMKERQITPDVYKVTPVMNTHPSQSEAVSDVWSLSKTSMTFQPKKASLQPLTISLD
FT                   ELFSSRGEFISVGGDGRMSHKEAILLGLRYKKLYNQARVKYSL"
FT   mRNA            2209. .3039
FT                   /product="M mRNA"
FT   CDS             2250. .2939
FT                   /codon_start=1
FT                   /db_xref="SWISS-PROT:P03519"
FT                   /note="matrix (M) protein"
FT                   /protein_id="AAA48369.1"
FT                   /translation="MSSLKKILGLKGKGKKSKKLGIAPPPYEEDTSMEYAPSAPIDKSY
FT                   FGVDEMDTYDPNQLRYEKFFFTVKMTVRSNRPFRTYSDVAAAVSHWDHMYIGMAGKRPF
FT                   YKILAFLGSSNLKATPAVLADQGQPEYHTHCEGRAYLPHRMGKTPPMLNVPEHFRRPFN
FT                   IGLYKGTIELTMTIYDDESLEAAPMIWDHFNSSKFSDFREKALMFGLIVEKKASGAWVL
FT                   DSISHFK"
FT   mRNA            3049. .4713
FT                   /product="G mRNA"
FT   sig_peptide     3078. .3125
FT                   /note="glycoprotein (G protein) signal peptide"
FT   CDS             3078. .4613
FT                   /codon_start=1
FT                   /db_xref="SWISS-PROT:P03522"
FT                   /note="glycoprotein (G protein) precursor"
FT                   /protein_id="AAA48370.1"
FT                   /translation="MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSD
FT                   LNWHNDLIGTAIQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITQSIRSFTPS
FT                   VEQCKESIEQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQ
FT                   FINGKCSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFR
FT                   SNYFAYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQT
FT                   SVDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLK
FT                   YFETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFP
FT                   LYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEGWF
FT                   SSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK"
FT   mat_peptide     3126. .4610
FT                   /product="glycoprotein (G protein) mature peptide"
FT   mRNA            4723. .11095
FT                   /product="L mRNA"
FT   CDS             4733. .11062
FT                   /codon_start=1
FT                   /db_xref="SPTREMBL:Q86125"
FT                   /note="polymerase (L protein)"
FT                   /protein_id="AAA48371.1"
FT                   /translation="MEVHDFETDEFNDFNEDDYATREFLNPDERMTYLNHADYNLNSPL
FT                   ISDDIDNLIRKFNSLPIPSMWDSKNWDGVLEMLTSCQANPISTSQMHKWMGSWLMSDNH
FT                   DASQGYSFLHEVDKEAEITFDVVETFIRGWGNKPIEYIKKERWTDSFKILAYLCQKFLD
FT                   LHKLTLILNAVSEVELLNLARTFKGKVRRSSHGTNICRIRVPSLGPTFISEGWAYFKKL
FT                   DILMDRNFLLMVKDVIIGRMQTVLSMVCRIDNLFSEQDIFSLLNIYRIGDKIVERQGNF
FT                   SYDLIKMVEPICNLKLMKLARESRPLVPQFPHFENHIKTSVDEGAKIDRGIRFLHDQIM
FT                   SVKTVDLTLVIYGSFRHWGHPFIDYYTGLEKLHSQVTMKKDIDVSYAKALASDLARIVL
FT                   FQQFNDHKKWFVNGDLLPHDHPFKSHVKENTWPTAAQVQDFGDKWHELPLIKCFEIPDL
FT                   LDPSIIYSDKSHSMNRSEVLKHVRMNPNTPIPSKKVLQTMLDTKATNWKEFLKEIDEKG
FT                   LDDDDLIIGLKGKERELKLAGRFFSLMSWKLREYFVITEYLIKTHFVPMFKGLTMADDL
FT                   TAVIKKMLDSSSGQGLKSYEAICIANHIDYEKWNNHQRKLSNGPVFRVMGQFLGYPSLI
FT                   ERTHEFFEKSLIYYNGRPDLMRVHNNTLINSTSQRVCWQGQEGGLEGLRQKGWTILNLL
FT                   VIQREAKIRNTAVKVLAQGDNQVICTQYKTKKSRNVVELQGALNQMVSNNEKIMTAIKI
FT                   GTGKLGLLINDDETMQSADYLNYGKIPIFRGVIRGLETKRWSRVTCVTNDQIPTCANIM
FT                   SSVSTNALTVAHFAENPINAMIQYNYFGTFARLLLMMHDPALRQSLYEVQDKIPGLHSS
FT                   TFKYAMLYLDPSIGGVSGMSLSRFLIRAFPDPVTESLSFWRFIHVHARSEHLKEMSAVF
FT                   GNPEIAKFRITHIDKLVEDPTSLNIAMGMSPANLLKTEVKKCLIESRQTIRNQVIKDAT
FT                   IYLYHEEDRLRSFLWSINPLFPRFLSEFKSGTFLGVADGLISLFQNSRTIRNSFKKKYH
FT                   RELDDLIVRSEVSSLTHLGKLHLRRGSCKMWTCSATHADTLRYKSWGRTVIGTTVPHPL
FT                   EMLGPQHRKETPCAPCNTSGFNYVSVHCPDGIHDVFSSRGPLPAYLGSKTSESTSILQP
FT                   WERESKVPLIKRATRLRDAISWFVEPDSKLAMTILSNIHSLTGEEWTKRQHGFKRTGSA
FT                   LHRFSTSRMSHGGFASQSTAALTRLMATTDTMRDLGDQNFDFLFQATLLYAQITTTVAR
FT                   DGWITSCTDHYHIACKSCLRPIEEITLDSSMDYTPPDVSHVLKTWRNGEGSWGQEIKQI
FT                   YPLEGNWKNLAPAEQSYQVGRCIGFLYGDLAYRKSTHAEDSSLFPLSIQGRIRGRGFLK
FT                   GLLDGLMRASCCQVIHRRSLAHLKRPANAVYGGLIYLIDKLSVSPPFLSLTRSGPIRDE
FT                   LETIPHKIPTSYPTSNRDMGVIVRNYFKYQCRLIEKGKYRSHYSQLWLFSDVLSIDFIG
FT                   PFSISTTLLQILYKPFLSGKDKNELRELANLSSLLRSGEGWEDIHVKFFTKDILLCPEE
FT                   IRHACKFGIAKDNNKDMSYPPWGRESRGTITTIPVYYTTTPYPKMLEMPPRIQNPLLSG
FT                   IRLGQLPTGAHYKIRSILHGMGIHYRDFLSCGDGSGGMTAALLRENVHSRGIFNSLLEL
FT                   SGSVMRGASPEPPSALETLGGDKSRCVNGETCWEYPSDLCDPRTWDYFLRLKAGLGLQI
FT                   DLIVMDMEVRDSSTSLKIETNVRNYVHRILDEQGVLIYKTYGTYICESEKNAVTILGPM
FT                   FKTVDLVQTEFSSSQTSEVYMVCKGLKKLIDEPNPDWSSINESWKNLYAFQSSEQEFAR
FT                   AKKVSTYFTLTGIPSQFIPDPFVNIETMLQIFGVPTGVSHAAALKSSDRPADLLTISLF
FT                   YMAIISYYNINHIRVGPIPPNPPSDGIAQNVGIAITGISFWLSLMEKDIPLYQQCLAVI
FT                   QQSFPIRWEAVSVKGGYKQKWSTRGDGLPKDTRTSDSLAPIGNWIRSLELVRNQVRLNP
FT                   FNEILFNQLCRTVDNHLKWSNLRRNTGMIEWINRRISKEDRSILMLKSDLHEENSWRD"
XX
SQ   Sequence 11161 BP; 3467 A; 2227 C; 2431 G; 3036 T; 0 other;

J02428  Length: 11161  December 21, 2001 15:45  Type: N  Check: 4851  ..

       1  acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt
      51  aacagtaatc aaaatgtctg ttacagtcaa gagaatcatt gacaacacag
     101  tcatagttcc aaaacttcct gcaaatgagg atccagtgga atacccggca
     151  gattacttca gaaaatcaaa ggagattcct ctttacatca atactacaaa
     201  aagtttgtca gatctaagag gatatgtcta ccaaggcctc aaatccggaa
     251  atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac
     301  atccggggta agttggataa agattggtca agtttcggaa taaacatcgg
     351  gaaagcaggg gatacaatcg gaatatttga ccttgtatcc ttgaaagccc
     401  tggacggcgt acttccagat ggagtatcgg atgcttccag aaccagcgca
     451  gatgacaaat ggttgccttt gtatctactt ggcttataca gagtgggcag
     501  aacacaaatg cctgaataca gaaaaaagct catggatggg ctgacaaatc
     551  aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt
     601  gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc
     651  tgcagtggac atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt
     701  tcagatacgg aactattgtt tccagattca aagattgtgc tgcattggca
     751  acatttggac acctctgcaa aataaccgga atgtctacag aagatgtaac
     801  gacctggatc ttgaaccgag aagttgcaga tgaaatggtc caaatgatgc
     851  ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc
     901  gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc
     951  cttccacttc tgggggcaat tgacagctct tctgctcaga tccaccagag
    1001  caaggaatgc ccgacagcct gatgacattg agtatacatc tcttactaca
    1051  gcaggtttgt tgtacgctta tgcagtagga tcctctgccg acttggcaca
    1101  acagttttgt gttggagata acaaatacac tccagatgat agtaccggag
    1151  gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc
    1201  ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta
    1251  tgcgaaaaga gcagtcatgt cactgcaagg cctaagagag aagacaattg
    1301  gcaagtatgc taagtcagaa tttgacaaat gaccctataa ttctcagatc
    1351  acctattata tattatgcta catatgaaaa aaactaacag atatcatgga
    1401  taatctcaca aaagttcgtg agtatctcaa gtcctattct cgtctggatc
    1451  aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc
    1501  aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc
    1551  ttattttcag gcagcagatg attctgacac agaatctgaa ccagaaattg
    1601  aagacaatca aggtttgtat gcacaggatc cagaagctga gcaagttgaa
    1651  ggctttatac aggggccttt agatgactat gcagatgagg aagtggatgt
    1701  tgtatttact tcggactgga aaccacctga gcttgaatct gacgagcatg
    1751  gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa
    1801  tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg
    1851  gaatctggca gagtgcacat ttgaagcatc gggagaaggg gtcattatga
    1901  aggagcgcca gataactccg gatgtatata aggtcactcc agtgatgaac
    1951  acacatccgt cccaatcaga agcagtatca gatgtttggt ctctctcaaa
    2001  gacatccatg actttccaac ccaagaaagc aagtcttcag cctctcacca
    2051  tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga
    2101  ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata
    2151  caaaaagttg tacaatcagg cgagagtcaa atattctctg tagactatga
    2201  aaaaaagtaa cagatatcac gatctaagtg ttatcccaat ccattcatca
    2251  tgagttcctt aaagaagatt ctcggtctga aggggaaagg taagaaatct
    2301  aagaaattag ggatcgcacc acccccttat gaagaggaca ctagcatgga
    2351  gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga
    2401  tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca
    2451  gtgaaaatga cggttagatc taatcgtccg ttcagaacat actcagatgt
    2501  ggcagccgct gtatcccatt gggatcacat gtacatcgga atggcaggga
    2551  aacgtccctt ctacaaaatc ttggcttttt tgggttcttc taatctaaag
    2601  gccactccag cggtattggc agatcaaggt caaccagagt atcacactca
    2651  ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca
    2701  tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac
    2751  aagggaacga ttgagctcac aatgaccatc tacgatgatg agtcactgga
    2801  agcagctcct atgatctggg atcatttcaa ttcttccaaa ttttctgatt
    2851  tcagagagaa ggccttaatg tttggcctga ttgtcgagaa aaaggcatct
    2901  ggagcgtggg tcctggattc tatcagccac ttcaaatgag ctagtctaac
    2951  ttctagcttc tgaacaatcc ccggtttact cagtctctcc taattccagc
    3001  ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa
    3051  cagagatcga tctgtttcct tgacactatg aagtgccttt tgtacttagc
    3101  ctttttattc attggggtga attgcaagtt caccatagtt tttccacaca
    3151  accaaaaagg aaactggaaa aatgttcctt ctaattacca ttattgcccg
    3201  tcaagctcag atttaaattg gcataatgac ttaataggca cagccataca
    3251  agtcaaaatg cccaagagtc acaaggctat tcaagcagac ggttggatgt
    3301  gtcatgcttc caaatgggtc actacttgtg atttccgctg gtatggaccg
    3351  aagtatataa cacagtccat ccgatccttc actccatctg tagaacaatg
    3401  caaggaaagc attgaacaaa cgaaacaagg aacttggctg aatccaggct
    3451  tccctcctca aagttgtgga tatgcaactg tgacggatgc cgaagcagtg
    3501  attgtccagg tgactcctca ccatgtgctg gttgatgaat acacaggaga
    3551  atgggttgat tcacagttca tcaacggaaa atgcagcaat tacatatgcc
    3601  ccactgtcca taactctaca acctggcatt ctgactataa ggtcaaaggg
    3651  ctatgtgatt ctaacctcat ttccatggac atcaccttct tctcagagga
    3701  cggagagcta tcatccctgg gaaaggaggg cacagggttc agaagtaact
    3751  actttgctta tgaaactgga ggcaaggcct gcaaaatgca atactgcaag
    3801  cattggggag tcagactccc atcaggtgtc tggttcgaga tggctgataa
    3851  ggatctcttt gctgcagcca gattccctga atgcccagaa gggtcaagta
    3901  tctctgctcc atctcagacc tcagtggatg taagtctaat tcaggacgtt
    3951  gagaggatct tggattattc cctctgccaa gaaacctgga gcaaaatcag
    4001  agcgggtctt ccaatctctc cagtggatct cagctatctt gctcctaaaa
    4051  acccaggaac cggtcctgct ttcaccataa tcaatggtac cctaaaatac
    4101  tttgagacca gatacatcag agtcgatatt gctgctccaa tcctctcaag
    4151  aatggtcgga atgatcagtg gaactaccac agaaagggaa ctgtgggatg
    4201  actgggcacc atatgaagac gtggaaattg gacccaatgg agttctgagg
    4251  accagttcag gatataagtt tcctttatac atgattggac atggtatgtt
    4301  ggactccgat cttcatctta gctcaaaggc tcaggtgttc gaacatcctc
    4351  acattcaaga cgctgcttcg caacttcctg atgatgagag tttatttttt
    4401  ggtgatactg ggctatccaa aaatccaatc gagcttgtag aaggttggtt
    4451  cagtagttgg aaaagctcta ttgcctcttt tttctttatc atagggttaa
    4501  tcattggact attcttggtt ctccgagttg gtatccatct ttgcattaaa
    4551  ttaaagcaca ccaagaaaag acagatttat acagacatag agatgaaccg
    4601  acttggaaag taactcaaat cctgcacaac agattcttca tgtttggacc
    4651  aaatcaactt gtgataccat gctcaaagag gcctcaatta tatttgagtt
    4701  tttaattttt atgaaaaaaa ctaacagcaa tcatggaagt ccacgatttt
    4751  gagaccgacg agttcaatga tttcaatgaa gatgactatg ccacaagaga
    4801  attcctgaat cccgatgagc gcatgacgta cttgaatcat gctgattaca
    4851  atttgaattc tcctctaatt agtgatgata ttgacaattt gatcaggaaa
    4901  ttcaattctc ttccgattcc ctcgatgtgg gatagtaaga actgggatgg
    4951  agttcttgag atgttaacat catgtcaagc caatcccatc tcaacatctc
    5001  agatgcataa atggatggga agttggttaa tgtctgataa tcatgatgcc
    5051  agtcaagggt atagtttttt acatgaagtg gacaaagagg cagaaataac
    5101  atttgacgtg gtggagacct tcatccgcgg ctggggcaac aaaccaattg
    5151  aatacatcaa aaaggaaaga tggactgact cattcaaaat tctcgcttat
    5201  ttgtgtcaaa agtttttgga cttacacaag ttgacattaa tcttaaatgc
    5251  tgtctctgag gtggaattgc tcaacttggc gaggactttc aaaggcaaag
    5301  tcagaagaag ttctcatgga acgaacatat gcaggattag ggttcccagc
    5351  ttgggtccta cttttatttc agaaggatgg gcttacttca agaaacttga
    5401  tattctaatg gaccgaaact ttctgttaat ggtcaaagat gtgattatag
    5451  ggaggatgca aacggtgcta tccatggtat gtagaataga caacctgttc
    5501  tcagagcaag acatcttctc ccttctaaat atctacagaa ttggagataa
    5551  aattgtggag aggcagggaa atttttctta tgacttgatt aaaatggtgg
    5601  aaccgatatg caacttgaag ctgatgaaat tagcaagaga atcaaggcct
    5651  ttagtcccac aattccctca ttttgaaaat catatcaaga cttctgttga
    5701  tgaaggggca aaaattgacc gaggtataag attcctccat gatcagataa
    5751  tgagtgtgaa aacagtggat ctcacactgg tgatttatgg atcgttcaga
    5801  cattggggtc atccttttat agattattac actggactag aaaaattaca
    5851  ttcccaagta accatgaaga aagatattga tgtgtcatat gcaaaagcac
    5901  ttgcaagtga tttagctcgg attgttctat ttcaacagtt caatgatcat
    5951  aaaaagtggt tcgtgaatgg agacttgctc cctcatgatc atccctttaa
    6001  aagtcatgtt aaagaaaata catggcccac agctgctcaa gttcaagatt
    6051  ttggagataa atggcatgaa cttccgctga ttaaatgttt tgaaataccc
    6101  gacttactag acccatcgat aatatactct gacaaaagtc attcaatgaa
    6151  taggtcagag gtgttgaaac atgtccgaat gaatccgaac actcctatcc
    6201  ctagtaaaaa ggtgttgcag actatgttgg acacaaaggc taccaattgg
    6251  aaagaatttc ttaaagagat tgatgagaag ggcttagatg atgatgatct
    6301  aattattggt cttaaaggaa aggagaggga actgaagttg gcaggtagat
    6351  ttttctccct aatgtcttgg aaattgcgag aatactttgt aattaccgaa
    6401  tatttgataa agactcattt cgtccctatg tttaaaggcc tgacaatggc
    6451  ggacgatcta actgcagtca ttaaaaagat gttagattcc tcatccggcc
    6501  aaggattgaa gtcatatgag gcaatttgca tagccaatca cattgattac
    6551  gaaaaatgga ataaccacca aaggaagtta tcaaacggcc cagtgttccg
    6601  agttatgggc cagttcttag gttatccatc cttaatcgag agaactcatg
    6651  aattttttga gaaaagtctt atatactaca atggaagacc agacttgatg
    6701  cgtgttcaca acaacacact gatcaattca acctcccaac gagtttgttg
    6751  gcaaggacaa gagggtggac tggaaggtct acggcaaaaa ggatggacta
    6801  tcctcaatct actggttatt caaagagagg ctaaaatcag aaacactgct
    6851  gtcaaagtct tggcacaagg tgataatcaa gttatttgca cacagtataa
    6901  aacgaagaaa tcgagaaacg ttgtagaatt acagggtgct ctcaatcaaa
    6951  tggtttctaa taatgagaaa attatgactg caatcaaaat agggacaggg
    7001  aagttaggac ttttgataaa tgacgatgag actatgcaat ctgcagatta
    7051  cttgaattat ggaaaaatac cgattttccg tggagtgatt agagggttag
    7101  agaccaagag atggtcacga gtgacttgtg tcaccaatga ccaaataccc
    7151  acttgtgcta atataatgag ctcagtttcc acaaatgctc tcaccgtagc
    7201  tcattttgct gagaacccaa tcaatgccat gatacagtac aattattttg
    7251  ggacatttgc tagactcttg ttgatgatgc atgatcctgc tcttcgtcaa
    7301  tcattgtatg aagttcaaga taagataccg ggcttgcaca gttctacttt
    7351  caaatacgcc atgttgtatt tggacccttc cattggagga gtgtcgggca
    7401  tgtctttgtc caggtttttg attagagcct tcccagatcc cgtaacagaa
    7451  agtctctcat tctggagatt catccatgta catgctcgaa gtgagcatct
    7501  gaaggagatg agtgcagtat ttggaaaccc cgagatagcc aagtttcgaa
    7551  taactcacat agacaagcta gtagaagatc caacctctct gaacatcgct
    7601  atgggaatga gtccagcgaa cttgttaaag actgaggtta aaaaatgctt
    7651  aatcgaatca agacaaacca tcaggaacca ggtgattaag gatgcaacca
    7701  tatatttgta tcatgaagag gatcggctca gaagtttctt atggtcaata
    7751  aatcctctgt tccctagatt tttaagtgaa ttcaaatcag gcactttttt
    7801  gggagtcgca gacgggctca tcagtctatt tcaaaattct cgtactattc
    7851  ggaactcctt taagaaaaag tatcataggg aattggatga tttgattgtg
    7901  aggagtgagg tatcctcttt gacacattta gggaaacttc atttgagaag
    7951  gggatcatgt aaaatgtgga catgttcagc tactcatgct gacacattaa
    8001  gatacaaatc ctggggccgt acagttattg ggacaactgt accccatcca
    8051  ttagaaatgt tgggtccaca acatcgaaaa gagactcctt gtgcaccatg
    8101  taacacatca gggttcaatt atgtttctgt gcattgtcca gacgggatcc
    8151  atgacgtctt tagttcacgg ggaccattgc ctgcttatct agggtctaaa
    8201  acatctgaat ctacatctat tttgcagcct tgggaaaggg aaagcaaagt
    8251  cccactgatt aaaagagcta cacgtcttag agatgctatc tcttggtttg
    8301  ttgaacccga ctctaaacta gcaatgacta tactttctaa catccactct
    8351  ttaacaggcg aagaatggac caaaaggcag catgggttca aaagaacagg
    8401  gtctgccctt cataggtttt cgacatctcg gatgagccat ggtgggttcg
    8451  catctcagag cactgcagca ttgaccaggt tgatggcaac tacagacacc
    8501  atgagggatc tgggagatca gaatttcgac tttttattcc aagcaacgtt
    8551  gctctatgct caaattacca ccactgttgc aagagacgga tggatcacca
    8601  gttgtacaga tcattatcat attgcctgta agtcctgttt gagacccata
    8651  gaagagatca ccctggactc aagtatggac tacacgcccc cagatgtatc
    8701  ccatgtgctg aagacatgga ggaatgggga aggttcgtgg ggacaagaga
    8751  taaaacagat ctatccttta gaagggaatt ggaagaattt agcacctgct
    8801  gagcaatcct atcaagtcgg cagatgtata ggttttctat atggagactt
    8851  ggcgtataga aaatctactc atgccgagga cagttctcta tttcctctat
    8901  ctatacaagg tcgtattaga ggtcgaggtt tcttaaaagg gttgctagac
    8951  ggattaatga gagcaagttg ctgccaagta atacaccgga gaagtctggc
    9001  tcatttgaag aggccggcca acgcagtgta cggaggtttg atttacttga
    9051  ttgataaatt gagtgtatca cctccattcc tttctcttac tagatcagga
    9101  cctattagag acgaattaga aacgattccc cacaagatcc caacctccta
    9151  tccgacaagc aaccgtgata tgggggtgat tgtcagaaat tacttcaaat
    9201  accaatgccg tctaattgaa aagggaaaat acagatcaca ttattcacaa
    9251  ttatggttat tctcagatgt cttatccata gacttcattg gaccattctc
    9301  tatttccacc accctcttgc aaatcctata caagccattt ttatctggga
    9351  aagataagaa tgagttgaga gagctggcaa atctttcttc attgctaaga
    9401  tcaggagagg ggtgggaaga catacatgtg aaattcttca ccaaggacat
    9451  attattgtgt ccagaggaaa tcagacatgc ttgcaagttc gggattgcta
    9501  aggataataa taaagacatg agctatcccc cttggggaag ggaatccaga
    9551  gggacaatta caacaatccc tgtttattat acgaccaccc cttacccaaa
    9601  gatgctagag atgcctccaa gaatccaaaa tcccctgctg tccggaatca
    9651  ggttgggcca attaccaact ggcgctcatt ataaaattcg gagtatatta
    9701  catggaatgg gaatccatta cagggacttc ttgagttgtg gagacggctc
    9751  cggagggatg actgctgcat tactacgaga aaatgtgcat agcagaggaa
    9801  tattcaatag tctgttagaa ttatcagggt cagtcatgcg aggcgcctct
    9851  cctgagcccc ccagtgccct agaaacttta ggaggagata aatcgagatg
    9901  tgtaaatggt gaaacatgtt gggaatatcc atctgactta tgtgacccaa
    9951  ggacttggga ctatttcctc cgactcaaag caggcttggg gcttcaaatt
   10001  gatttaattg taatggatat ggaagttcgg gattcttcta ctagcctgaa
   10051  aattgagacg aatgttagaa attatgtgca ccggattttg gatgagcaag
   10101  gagttttaat ctacaagact tatggaacat atatttgtga gagcgaaaag
   10151  aatgcagtaa caatccttgg tcccatgttc aagacggtcg acttagttca
   10201  aacagaattt agtagttctc aaacgtctga agtatatatg gtatgtaaag
   10251  gtttgaagaa attaatcgat gaacccaatc ccgattggtc ttccatcaat
   10301  gaatcctgga aaaacctgta cgcattccag tcatcagaac aggaatttgc
   10351  cagagcaaag aaggttagta catactttac cttgacaggt attccctccc
   10401  aattcattcc tgatcctttt gtaaacattg agactatgct acaaatattc
   10451  ggagtaccca cgggtgtgtc tcatgcggct gccttaaaat catctgatag
   10501  acctgcagat ttattgacca ttagcctttt ttatatggcg attatatcgt
   10551  attataacat caatcatatc agagtaggac cgatacctcc gaacccccca
   10601  tcagatggaa ttgcacaaaa tgtggggatc gctataactg gtataagctt
   10651  ttggctgagt ttgatggaga aagacattcc actatatcaa cagtgtttag
   10701  cagttatcca gcaatcattc ccgattaggt gggaggctgt ttcagtaaaa
   10751  ggaggataca agcagaagtg gagtactaga ggtgatgggc tcccaaaaga
   10801  tacccgaact tcagactcct tggccccaat cgggaactgg atcagatctc
   10851  tggaattggt ccgaaaccaa gttcgtctaa atccattcaa tgagatcttg
   10901  ttcaatcagc tatgtcgtac agtggataat catttgaaat ggtcaaattt
   10951  gcgaagaaac acaggaatga ttgaatggat caatagacga atttcaaaag
   11001  aagaccggtc tatactgatg ttgaagagtg acctacacga ggaaaactct
   11051  tggagagatt aaaaaatcat gaggagactc caaactttaa gtatgaaaaa
   11101  aactttgatc cttaagaccc tcttgtggtt tttatttttt atctggtttt
   11151  gtggtcttcg t