Notes on Genus: Ferlavirus

enveloped spheres

Type member: Fer-de-Lance paramyxovirus

Contents

• Members of this Genus
• General Description
• Morphology
• Electron Micrograph
• Genome
• Genus Genomic Organization
• Genome Map
• Type Member Genomic Organization
• All Known Sequences
• Curated Sequences

General Description

The genus Ferlavirus is one of nine genera in the family Paramyxoviridae and contains contains viruses that infect reptiles. The name is derived from the type species, Fer-de-Lance paramyxovirus.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 8 transcriptional elements (mRNA species). There is no C protein and the phosphprotein P is produced from an edited transcript.

Type Member Genomic Organization

There are 8 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:

1    	N	51 kDa	Coat protein (nucleocapsid)
2	X	19 kDa	Unkown ORF
3	P	47 kDa	Phosphoprotein produced by RNA editing
4	V	25 kDa	Non-structural protein from same mRNA transcript as P but in a different reading frame
5	M	38 kDa	Matrix protein
6	F	58 kDa	Fusion protein: glycosylated envelope protein
7	HN	62 kDa	Hemagglutinin-neuraminidase attachment protein
8	L	247 kDa	Polymerase