Notes on Genus: Lyssavirus

enveloped bacilliform
enveloped bacilliform

Type member: Rabies virus


General Description

This is one of the animal virus genera in the family Rhabdoviridae. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is less than 12kb in size and by having members that are not transmitted by arthropod vectors. The name is taken from the greek lyssa (rage, or fury: the symptoms of infection by the type member).


Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.


Monopartite, linear, single-stranded, negative sense RNA, about 12000 nucleotides long.

Genus Genomic Organization

There are the five structural proteins common to all members of the family.

Type Member Genomic Organization

The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):
  Gene     ProductFunction
1N 50.6 kDaCoat protein (nucleocapsid)
2P33.1 kDaPolymerase-associated phosphoprotein (NS)
3M 23.1 kdaMatrix protein
4G58.5 kda Glycoprotein produced from a 57.5 kDa precursor
5L244.5 kDa   Polyprotein with replicase and other functions