Notes on Genus: Lyssavirus

enveloped bacilliform

Type member: Rabies virus

Contents

• Members of this Genus
• General Description
• Morphology
• Electron Micrograph
• Genome
• Genus Genomic Organization
• Genome Map
• Type Member Genomic Organization
• All Known Sequences
• Curated Sequences

General Description

This is one of the animal virus genera in the family Rhabdoviridae. The genus is characterised by its bacilliform, enveloped, particles which contain a monopartite ssRNA genome that is less than 12kb in size and by having members that are not transmitted by arthropod vectors. The name is taken from the greek lyssa (rage, or fury: the symptoms of infection by the type member).

Morphology

Virions are bullet- or cone-shaped, about 140-200 nm long and 60-80 nm in diameter.

Genome

Monopartite, linear, single-stranded, negative sense RNA, about 12000 nucleotides long.

Genus Genomic Organization

There are the five structural proteins common to all members of the family.

Type Member Genomic Organization

The genes are listed here in their order on the template strand (i.e. from 3' to 5' with respect to the virion strand):

ORF
  Gene    	Product	Function
1	N	50.6 kDa	Coat protein (nucleocapsid)
2	P	33.1 kDa	Polymerase-associated phosphoprotein (NS)
3	M	23.1 kda	Matrix protein
4	G	58.5 kda	Glycoprotein produced from a 57.5 kDa precursor
5	L	244.5 kDa  	Polyprotein with replicase and other functions