Notes on Genus: Morbillivirus

enveloped spheres
enveloped spheres

Type member: Measles virus

Contents

General Description

The genus Morbillivirus is one of nine genera in the family Paramyxoviridae and contains contains viruses that produce a non-strutural protein C, a hemagglutinin attachment protein and translate protein V from an edited RNA transcript. It is named from the Latin morbus = disease.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N58 kDa Coat protein (nucleocapsid)
2P 54-55 kDa Phosphoprotein
3C20-21 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame
4V32 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 59-73 kDa Fusion protein: glycosylated envelope protein
7H68-69 kDa Hemagglutinin attachment protein
8L      248 kDa Polymerase

Type Member Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N58 kDa Coat protein (nucleocapsid)
2P 54 kDa Phosphoprotein
3C21 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame
4V32 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 60 kDa Fusion protein: glycosylated envelope protein
7H69 kDa Hemagglutinin attachment protein
8L      248 kDa Polymerase