Notes on Genus: Respirovirus

enveloped spheres
enveloped spheres

Type member: Sendai virus

Contents

General Description

The genus Respirovirus is one of nine genera in the family Paramyxoviridae and contains viruses that produce a non-strutural protein C, a hemagglutinin-neuraminidase attachment protein and translate protein V from an edited RNA transcript. It is named after the Latin respirare = to breathe.

Morphology

Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.

Genome

Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N57-58 kDa Coat protein (nucleocapsid)
2P 63-67 kDa Phosphoprotein
3C24-26 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame; some isolates may also produce a shorter Y1 (21 kDa) protein
4V24 kDa Produced from the P transcript by RNA editing in some viruses: shares the N-terminus of P but then has a frame shift
5M38-40 kDa Matrix protein
6F 60-61 kDa Fusion protein: glycosylated envelope protein
7HN63-65 kDa Hemagglutinin-neuraminidase attachment protein
8L 253-259 kDa Polymerase

Type Member Genomic Organization

There are 6 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:
1    N57 kDa Coat protein (nucleocapsid)
2P 63 kDa Phosphoprotein
3C24 kDa Non-structural protein from same mRNA transcript as P but in a different reading frame; some isolates may also produce a shorter Y1 (21.3 kDa) protein
4V40 kDa Produced from the P transcript by RNA editing: shares the N-terminus of P but then has a frame shift
5M38 kDa Matrix protein
6F 61 kDa Fusion protein: glycosylated envelope protein
7HN63 kDa Hemagglutinin-neuraminidase attachment protein
8L      253 kDa Polymerase