Notes on Genus: Alphatorquevirus

icosahedra
icosahedra

Type member: Torque teno virus 1

Contents

General Description

This is one of the genera in the family Anelloviridae and contains viruses previously classified as Torque teno virus. The viruses infect primates and have genomes of up to 3.9 kb (larger than in some of the other genera). The genus name is partly derived from the latin torques, for necklace which reflects the circular nature of the genome.

Morphology

Virions isometric (icosahedral), not enveloped, 19-27 nm in diameter.

Genome

Monopartite circular single-stranded DNA of 3.1-3.9 kb.

Genus Genomic Organization

There are two major overlapping ORFs encoding a replication-associated protein and a (larger) coat protein. Further products may also be generated by splicing of an intron. Additional ORFs may be present in some isolates.

Type Member Genomic Organization

There are two major overlapping ORFs:
  • ORF1: 90 kDa, Coat protein
  • ORF2: 21 kDa, Replication protein (one or two proteins of about 30 kDa may also be generated by splicing of introns)