Notes on Family: Filoviridae
eveloped filaments or bacilliform
This family is characterised by its pleomorphic but usually filamentous or bacilliform, enveloped, particles which contain a monopartite negative sense ssRNA genome of about 19kb. It is classified in the order Mononegavirales
with three other families of enveloped viruses with monopartite negative sense genomes, i.e. the Bornaviridae
(both with spherical particles) and Rhabdoviridae
(particles bullet-shaped and genome up to about 15 kb).
Virions pleomorphic but usually filamentous or bacilliform, enveloped, about 80 nm in diameter and up to about 970nm long (although they may appear longer because of aggregation), with small (10 nm) projections.
Monopartite single-stranded negative sense RNA of about 19 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail. There are 7 major ORFs with the RNA polymerase at the 5'-end of the genome and the capsid nucleoprotein at the 3'-end.
Genera in the Family